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A. Jerad Suresh ¹, A. Mohan Kumar ¹, T. Suyaraj ¹, D. Vinod ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai - 600003, IN

Abstract

A study was carried out using Reverse Phase High Performance Liquid Chromatography to determine the stability of four different brands of formulation (capsules) containing Amoxicillin and Dicloxacillin. Five batches of four different brands expiring in consecutive months (7^th, 8^th, 9^th, 10^th and 12^th month of 2010) were obtained and studied. During 5 months study, all the five batches were stored at room temperature (NMT 25°C). The 5 batches were assayed periodically at one month interval by Reverse Phase High Performance Liquid Chromatography method. The Dicloxacillin content in all the 5 batches steadily decreased over the months indicating that formulations of Amoxicillin and Dicloxacillin, which are available in the market are generally unstable. The Dicloxacillin content also reached 0% in some of these batches.

Keywords

HPLC, Amoxicillin, Dicloxacillin, Stability, Degradation Rate.

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A. Jerad Suresh ¹, A. Mohan Kumar ¹, S. Prabhu ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IN

Abstract

A study was carried out using LC-MASS Spectroscopy to determine the degradation products of formulation (capsules) containing Amoxicillin and Dicloxacillin. Previously an RP-HPLC method was performed to determine the stability of five batches of four different brands of formulation (capsules) containing Amoxicillin and Dicloxacillin which were expiring in consecutive months (7^th, 8^th, 9^th, 10^th and 12^th month of 2010). The Dicloxacillin content in all the five batches steadily decreased over the period of consecutive 5 month Assays (one month interval between each Assays), thereby determined the degradation product of Dicloxacillin by LC-MASS Spectroscopy.

Keywords

LC-MASS Spectroscopy, RP-HPLC, Amoxicillin, Dicloxacillin, Degradation Product.

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